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MTMR5 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O95248
Clone Names 2020802
Peptide ID 2020802
Additional Information
Gene ID 6305
Other Names Myotubularin-related protein 5, SET-binding factor 1, Sbf1, SBF1, MTMR5
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6805a was selected from the C-term region of human MTMR5 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SBF1
Synonyms MTMR5
Function Probable pseudophosphatase. Lacks several amino acids in the catalytic pocket which renders it catalytically inactive as a phosphatase. The pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases. Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts. According to PubMed:20937701, may function as a guanine nucleotide exchange factor (GEF) activating RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
Cellular Location Nucleus.
Research Areas
Citations (0)

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The myotubularin (MTM) family constitutes one of the largest and most highly conserved protein-tyrosine phosphatase (PTP) subfamilies. Myotubularins, contain the consensus active site of tyrosine phosphatases but otherwise shows no homology to other phosphatases. PTP's usually act on substrates containing only phosphotyrosine sites, but myotubularins were shown to act on both phosphotyrosine and phosphoserine (dual specific). The enzymatic activity of myotubularins had not been demonstrated previously because it lacks catalytically active residues in tyrosine phosphatase/dual-specific phosphatase active site. The active site is however sufficiently preserved to bind phosphorylated substrates, and may protect from phosphatases. It was reported that interaction of myotubularin family members makes one of them catalytically active. MTMR5 can interact with MTMR2 and regulates the enzymatic activity and the subcellular localization of MTMR2. MTMR5 inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts.Other suggested roles for MTMR5 are in spermatogenesis and germ cell differentiation. Binding partners for MTMR5 include the SET domain of MLL/HRX and SUV39H1.


Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).Firestein, R., et al., Mol. Cell. Biol. 20(13):4900-4909 (2000).Dunham, I., et al., Nature 402(6761):489-495 (1999).Laporte, J., et al., Hum. Mol. Genet. 7(11):1703-1712 (1998).

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$ 80.00
Cat# BP6805a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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