|Other Names||Arylacetamide deacetylase, AADAC, DAC|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6805b was selected from the C-term region of human AADAC. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein|
|Tissue Location||Detected in liver (at protein level). Mainly expressed in liver, small intestine, colon, adrenal gland and bladder.|
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Provided below are standard protocols that you may find useful for product applications.
Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens.
Saito,S., et.al., J. Hum. Genet. 48 (5), 249-270 (2003)
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