MTMR7 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y216 |
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Gene ID | 9108 |
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Other Names | Myotubularin-related protein 7, 313-, MTMR7 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6807a was selected from the C-term region of human MTMR7 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | MTMR7 |
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Function | Phosphatase that specifically dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and inositol 1,3- bisphosphate (Ins(1,3)P2). |
Cellular Location | Cytoplasm. Endomembrane system {ECO:0000250|UniProtKB:Q9Z2C9}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Z2C9}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z2C9}. Note=May partially localize to endosomes and/or the Golgi apparatus. {ECO:0000250|UniProtKB:Q9Z2C9} |
Tissue Location | Expressed specifically in brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Mtmr7 is a member of the myotubularin (MTM) family. In mouse cells, MTMR7 is expressed mainly in brain and neuroblastoma. Recombinant MTMR7 dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. Immunofluorescence data shows that MTMR7 is localized in Golgi-like granules and cytosol, and subcellular fractionation showed both cytoplasmic and membrane localization of MTMR7 in neuronal cells. Binding of MTMR9 increases the phosphatase activity of MTMR7.
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