|Other Names||Myotubularin-related protein 7, 313-, MTMR7|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6807a was selected from the C-term region of human MTMR7 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Phosphatase that acts on lipids with a phosphoinositol headgroup.|
|Tissue Location||Expressed specifically in brain.|
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Provided below are standard protocols that you may find useful for product applications.
Mtmr7 is a member of the myotubularin (MTM) family. In mouse cells, MTMR7 is expressed mainly in brain and neuroblastoma. Recombinant MTMR7 dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. Immunofluorescence data shows that MTMR7 is localized in Golgi-like granules and cytosol, and subcellular fractionation showed both cytoplasmic and membrane localization of MTMR7 in neuronal cells. Binding of MTMR9 increases the phosphatase activity of MTMR7.
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