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TPTEa Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P56180
Clone Names 3110608
Additional Information
Other Names Putative tyrosine-protein phosphatase TPTE, Cancer/testis antigen 44, CT44, Transmembrane phosphatase with tensin homology, Tumor antigen BJ-HCC-5, TPTE
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6811a was selected from the N-term region of human TPTEa . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TPTE
Function Could be involved in signal transduction.
Cellular Location Membrane; Multi-pass membrane protein.
Tissue Location Exclusively expressed in testis. EMBL; AF007118; AAC34574.1; -; mRNA EMBL; AY219886; AAP45143.1; -; mRNA EMBL; AY219887; AAP45144.1; -; mRNA EMBL; AY219888; AAP45145.1; -; mRNA EMBL; AF495908; AAQ06674.1; -; mRNA EMBL; AK314285; BAG36944.1; -; mRNA EMBL; AF254982; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AF254983; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AL078471; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; AL163201; CAB90528.1; -; Genomic_DNA EMBL; BC028719; AAH28719.1; -; mRNA CCDS; CCDS74771.1; -. [P56180-1] CCDS; CCDS74772.1; -. [P56180-2] CCDS; CCDS74773.1; -. [P56180-3] CCDS; CCDS77617.1; -. [P56180-4] RefSeq; NP_001277153.1; NM_001290224.1 RefSeq; NP_954868.1; NM_199259.3 RefSeq; NP_954869.1; NM_199260.3 RefSeq; NP_954870.2; NM_199261.3 UniGene; Hs.122986; - ProteinModelPortal; P56180; - SMR; P56180; - BioGrid; 113031; 62 IntAct; P56180; 51 STRING; 9606.ENSP00000355208; - DEPOD; P56180; - iPTMnet; P56180; - PhosphoSitePlus; P56180; - BioMuta; TPTE; - DMDM; 313104272; - PaxDb; P56180; - PeptideAtlas; P56180; - PRIDE; P56180; - ProteomicsDB; 56895; - ProteomicsDB; 56896; -. [P56180-2] ProteomicsDB; 56897; -. [P56180-3] ProteomicsDB; 56898; -. [P56180-4] DNASU; 7179; - Ensembl; ENST00000427445; ENSP00000482488; ENSG00000274391. [P56180-3] Ensembl; ENST00000612746; ENSP00000483087; ENSG00000274391. [P56180-4] Ensembl; ENST00000618007; ENSP00000484403; ENSG00000274391. [P56180-1] Ensembl; ENST00000622113; ENSP00000482040; ENSG00000274391. [P56180-2] GeneID; 7179; - KEGG; hsa:7179; - UCSC; uc002yip.2; human. [P56180-1] CTD; 7179; - DisGeNET; 7179; - EuPathDB; HostDB:ENSG00000274391.4; - GeneCards; TPTE; - HGNC; HGNC:12023; TPTE HPA; HPA049690; - HPA; HPA068342; - MIM; 604336; gene neXtProt; NX_P56180; - OpenTargets; ENSG00000274391; - PharmGKB; PA36702; - eggNOG; KOG2283; Eukaryota eggNOG; COG2453; LUCA GeneTree; ENSGT00760000119113; - HOVERGEN; HBG084209; - InParanoid; P56180; - KO; K18079; - OMA; AHYNANE; - OrthoDB; EOG091G09VG; - PhylomeDB; P56180; - TreeFam; TF354329; - Reactome; R-HSA-1660514; Synthesis of PIPs at the Golgi membrane GeneWiki; TPTE; - GenomeRNAi; 7179; - PRO; PR:P56180; - Proteomes; UP000005640; Chromosome 21 Bgee; ENSG00000274391; - CleanEx; HS_TPTE; - ExpressionAtlas; P56180; baseline and differential Genevisible; P56180; HS GO; GO:0016021; C:integral component of membrane; TAS:ProtInc GO; GO:0004725; F:protein tyrosine phosphatase activity; TAS:ProtInc GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro GO; GO:0006470; P:protein dephosphorylation; TAS:ProtInc GO; GO:0007165; P:signal transduction; TAS:ProtInc Gene3D; 1.20.120.350; -; 1 Gene3D; 3.90.190.10; -; 1 InterPro; IPR000340; Dual-sp_phosphatase_cat-dom InterPro; IPR029021; Prot-tyrosine_phosphatase-like InterPro; IPR014020; Tensin_C2-dom InterPro; IPR029023; Tensin_phosphatase InterPro; IPR016130; Tyr_Pase_AS InterPro; IPR027359; Volt_channel_dom_sf Pfam; PF00782; DSPc; 1 Pfam; PF10409; PTEN_C2; 1 SMART; SM01326; PTEN_C2; 1 SUPFAM; SSF52799; SSF52799; 1 PROSITE; PS51182; C2_TENSIN; 1 PROSITE; PS51181; PPASE_TENSIN; 1 2: Evidence at transcript level; Alternative splicing; Complete proteome; Hydrolase; Membrane; Polymorphism; Protein phosphatase; Reference proteome; Transmembrane; Transmembrane helix CHAIN 1 551 Putative tyrosine-protein phosphatase TPTE /FTId=PRO_0000215907 TRANSMEM 91 111 Helical. TRANSMEM 128 148 Helical. TRANSMEM 164 184 Helical. DOMAIN 228 404 Phosphatase tensin-type {ECO:0000255|PROSITE-ProRule:PRU00590} DOMAIN 411 540 C2 tensin-type. {ECO:0000255|PROSITE- ProRule:PRU00589} ACT_SITE 338 338 VAR_SEQ 1 138 Missing (in isoform 4) /FTId=VSP_017319 VAR_SEQ 41 78 Missing (in isoform 3) /FTId=VSP_017320 VAR_SEQ 41 58 Missing (in isoform 2) {ECO:0000303|PubMed:14659893, ECO:0000303|PubMed:15489334, ECO:0000303|Ref.3} /FTId=VSP_017321 VARIANT 144 144 R -> Q (in a breast cancer sample; somatic mutation; dbSNP:rs144333919) /FTId=VAR_036516 VARIANT 195 195 R -> Q (in dbSNP:rs1810856) /FTId=VAR_057347 VARIANT 386 386 K -> E (in dbSNP:rs212146) {ECO:0000269|PubMed:10598804, ECO:0000269|PubMed:14659893, ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334, ECO:0000269|Ref.3} /FTId=VAR_065097 VARIANT 470 470 L -> P (in dbSNP:rs150482) /FTId=VAR_025400 VARIANT 482 482 Y -> S (in dbSNP:rs9996) /FTId=VAR_061895 VARIANT 549 549 G -> E (in dbSNP:rs169758) /FTId=VAR_057348 SEQUENCE 551 AA; 64322 MW; 48C2F28BEAA0DDA6 CRC64; MNESPDPTDL AGVIIELGPN DSPQTSEFKG ATEEAPAKES PHTSEFKGAA RVSPISESVL ARLSKFEVED AENVASYDSK IKKIVHSIVS SFAFGLFGVF LVLLDVTLIL ADLIFTDSKL YIPLEYRSIS LAIALFFLMD VLLRVFVERR QQYFSDLFNI LDTAIIVILL LVDVVYIFFD IKLLRNIPRW THLLRLLRLI ILLRIFHLFH QKRQLEKLIR RRVSENKRRY TRDGFDLDLT YVTERIIAMS FPSSGRQSFY RNPIKEVVRF LDKKHRNHYR VYNLCSERAY DPKHFHNRVV RIMIDDHNVP TLHQMVVFTK EVNEWMAQDL ENIVAIHCKG GTDRTGTMVC AFLIASEICS TAKESLYYFG ERRTDKTHSE KFQGVKTPSQ KRYVAYFAQV KHLYNWNLPP RRILFIKHFI IYSIPRYVRD LKIQIEMEKK VVFSTISLGK CSVLDNITTD KILIDVFDGL PLYDDVKVQF FYSNLPTYYD NCSFYFWLHT SFIENNRLYL PKNELDNLHK QKARRIYPSD FAVEILFGEK MTSSDVVAGS D
Research Areas
Citations (0)

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Background

Ubiquitin is a 76 amino acid highly conserved eukaryotic polypeptide that selectively marks cellular proteins for proteolytic degradation by the 26S proteasome. The process of target selection, covalent attachment and shuttle to the 26S proteasome is a vital means of regulating the concentrations of key regulatory proteins in the cell by limiting their lifespans. Polyubiquitination is a common feature of this modification. Serial steps for modification include the activation of ubiquitin, an ATP-dependent formation of a thioester bond between ubiquitin and the enzyme E1, transfer by transacylation of ubiquitin from E1 to the ubiquitin conjugating enzyme E2, and covalent linkage to the target protein directly by E2 or via E3 ligase enzyme. Deubiquitination enzymes also exist to reverse the marking of protein substrates. Posttranslational tagging by Ub is involved in a multitude of cellular processes, including the cell cycle, cell growth and differentiation, embryogenesis, apoptosis, signal transduction, DNA repair, regulation of transcription and DNA replication, transmembrane transport, stress responses, the immune response, and nervous system functions.

References

Hattori, M., et al., Nature 405(6784):311-319 (2000).Chen, H., et al., Hum. Genet. 105(5):399-409 (1999).

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$ 80.00
Cat# BP6811a
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