|Other Names||Helicase-like transcription factor, 364-, 632-, DNA-binding protein/plasminogen activator inhibitor 1 regulator, HIP116, RING finger protein 80, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3, Sucrose nonfermenting protein 2-like 3, HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6812c was selected from the Center region of human HIP116A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1|
|Function||Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.|
|Cellular Location||Cytoplasm. Nucleus. Nucleus, nucleolus Nucleus, nucleoplasm. Note=Nuclear localization is stimulated by progesterone.|
|Tissue Location||Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
HIP116A is a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. This protein contains a RING finger DNA binding motif.
Ding,H., et.al., DNA Cell Biol. 15 (6), 429-442 (1996)
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