|Other Names||Transcription termination factor 2, 364-, Lodestar homolog, RNA polymerase II termination factor, Transcription release factor 2, F2, HuF2, TTF2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6813a was selected from the N-term region of human TTF2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.|
|Cellular Location||Cytoplasm. Nucleus. Note=Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis|
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Provided below are standard protocols that you may find useful for product applications.
TTF2 is a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. This protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing.
Tonacchera,M., et.al., Thyroid 14 (8), 584-588 (2004)
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