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SLC38A3 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q99624 |
|---|---|
| Clone Names | 81201107 |
| Gene ID | 10991 |
|---|---|
| Other Names | Sodium-coupled neutral amino acid transporter 3, N-system amino acid transporter 1, Na(+)-coupled neutral amino acid transporter 3, Solute carrier family 38 member 3, System N amino acid transporter 1, SLC38A3 {ECO:0000312|EMBL:AAH428751} |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6819c was selected from the Center region of human SLC38A3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC38A3 {ECO:0000312|EMBL:AAH42875.1, ECO:0000312|MIM:604437} |
|---|---|
| Function | Symporter that cotransports specific neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:10823827). Mainly participates in the glutamate-GABA-glutamine cycle in brain where it transports L-glutamine from astrocytes in the intercellular space for the replenishment of both neurotransmitters glutamate and gamma-aminobutyric acid (GABA) in neurons and also functions as the major influx transporter in ganglion cells mediating the uptake of glutamine (By similarity). The transport activity is specific for L- glutamine, L-histidine and L-asparagine (PubMed:10823827). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). The transport is pH dependent, saturable, Li(+) tolerant and functions in both direction depending on the concentration gradients of its substrates and cotransported ions (PubMed:10823827). Also mediates an amino acid-gated H(+) conductance that is not stoichiometrically coupled to the amino acid transport but which influences the ionic gradients that drive the amino acid transport (By similarity). In addition, may play a role in nitrogen metabolism, amino acid homeostasis, glucose metabolism and renal ammoniagenesis (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q9DCP2}; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000250|UniProtKB:Q9DCP2}. Note=The localization appears to be basolateral in the plasma membrane of hepatocytes surrounding the central vein. Localized at the cerebrospinal fluid (CSF)-facing membrane of the choroid plexus epithelial cells. In astrocytes, the localization at cell membrane is decreased by ammonia through the PKC signaling. Expressed in both luminal and abluminal plasma membranes of larger microvessels and blood brain barrier (BBB) capillaries (By similarity). Restricted to the basolateral membranes of S3 segment cells of the proximal tubules (By similarity) {ECO:0000250|UniProtKB:Q9DCP2, ECO:0000250|UniProtKB:Q9JHZ9} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
SLC38A3 is sodium-dependent amino acid/proton antiporter.It mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons and also recognizes histidine, asparagine and alanine. This protein may mediate amino acid transport in either direction under physiological conditions. It may play a role in nitrogen metabolism and synaptic transmission.
References
Sidoryk,M., et.al., Neuroreport 15 (4), 575-578 (2004)
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