ASS Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P00966 |
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Clone Names | 90121073 |
Gene ID | 445 |
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Other Names | Argininosuccinate synthase, Citrulline--aspartate ligase, ASS1, ASS |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6829c was selected from the Center region of human ASS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ASS1 (HGNC:758) |
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Function | One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues. |
Cellular Location | Cytoplasm, cytosol |
Tissue Location | Expressed in adult liver. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ASS catalyzes the penultimate step of the arginine biosynthetic pathway. There are approximately 10 to 14 copies of this gene including the pseudogenes scattered across the human genome, among which the one located on chromosome 9 appears to be the only functional gene for argininosuccinate synthetase.
References
Engel,K., et.al., Hum. Mutat. 30 (3), 300-307 (2009)
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