TLE2 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q04725 |
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Clone Names | 80924251 |
Gene ID | 7089 |
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Other Names | Transducin-like enhancer protein 2, Enhancer of split groucho-like protein 2, ESG2, TLE2 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6833c was selected from the Center region of human TLE2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TLE2 |
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Function | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full- length TLE family members may be modulated by association with dominant-negative AES (By similarity). |
Cellular Location | Nucleus. |
Tissue Location | In all tissues examined, mostly in heart, brain, and muscle |
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Provided below are standard protocols that you may find useful for product applications.
Background
TLE2 is a transcriptional corepressor that binds to a number of transcription factors. It inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
References
Javed,A., et.al., J. Cell. Sci. 113 (PT 12), 2221-2231 (2000)
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