|Other Names||Transducin-like enhancer protein 2, Enhancer of split groucho-like protein 2, ESG2, TLE2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6833c was selected from the Center region of human TLE2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).|
|Tissue Location||In all tissues examined, mostly in heart, brain, and muscle|
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Provided below are standard protocols that you may find useful for product applications.
TLE2 is a transcriptional corepressor that binds to a number of transcription factors. It inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
Javed,A., et.al., J. Cell. Sci. 113 (PT 12), 2221-2231 (2000)
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