IER2 Antibody (Center P113) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9BTL4 |
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Clone Names | 81110093 |
Gene ID | 9592 |
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Other Names | Immediate early response gene 2 protein, Protein ETR101, IER2, ETR101 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6835f was selected from the Center region of human IER2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | IER2 (HGNC:28871) |
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Function | DNA-binding protein that seems to act as a transcription factor (PubMed:19584537). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (By similarity). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (PubMed:22120713). |
Cellular Location | Cytoplasm. Nucleus. Note=Cytoplasmic during quiescence, translocates to the nucleus upon stimulation |
Tissue Location | Expressed in activated T-cells (at protein level) (PubMed:22120713). Expression increases in metastatic tumor cells (at protein level) (PubMed:22120713). |
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Provided below are standard protocols that you may find useful for product applications.
Background
IER2 belongs to a family of immediate early response proteins, and it is thought to play a role in mediating the cellular responses to a variety of extracellular signals.
References
Takaya,T., et.al., Biosci. Biotechnol. Biochem. 73 (7), 1653-1660 (2009)
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