|Other Names||Mevalonate kinase, MK, MVK|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6839c was selected from the Center region of human MVK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be a regulatory site in cholesterol biosynthetic pathway.|
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Provided below are standard protocols that you may find useful for product applications.
MVK is the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises.
Junyent,M., et.al., Am. J. Clin. Nutr. 90 (3), 686-694 (2009)Graef,E., et.al., Oncogene 9 (1), 81-87 (1994)
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