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TCPR1 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q7Z6L1
Clone Names 81231009
Additional Information
Gene ID 25851
Other Names Tectonin beta-propeller repeat-containing protein 1, TECPR1, KIAA1358
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6845a was selected from the N-term region of human TCPR1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TECPR1
Synonyms KIAA1358
Function Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.
Cellular Location Cytoplasmic vesicle, autophagosome membrane. Lysosome membrane. Note=Localizes to Lysosome membranes, and binds PtdIns(3)P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes
Research Areas
Citations (0)
citation

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References

Scherer,S.W., et.al., Science 300 (5620), 767-772 (2003)

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$ 277.78
Cat# BP6845a
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