|Other Names||WD repeat and SOCS box-containing protein 2, WSB-2, CS box-containing WD protein, WSB2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6853a was selected from the N-term region of human WSB2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.|
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Provided below are standard protocols that you may find useful for product applications.
WSB2 is a member of the WD-protein subfamily. This protein contains five WD-repeats spanning most of the protein and an SOCS box in the C-terminus. The SOCS box may act as a bridge between specific substrate-binding domains and E3 ubiquitin protein ligases.
Kile,B.T., et.al., Trends Biochem. Sci. 27 (5), 235-241 (2002)
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