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ZYX Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q15942 |
|---|---|
| Clone Names | 80924301 |
| Gene ID | 7791 |
|---|---|
| Other Names | Zyxin, Zyxin-2, ZYX |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6854b was selected from the C-term region of human ZYX. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ZYX |
|---|---|
| Function | Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion- stimulated changes in gene expression (By similarity). |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Cell junction, focal adhesion. Note=Associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1 |
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Provided below are standard protocols that you may find useful for product applications.
Background
ZYX binds alpha-actinin and the CRP protein. It may be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression.
References
Moon,H.S., et.al., Exp. Cell Res. 312 (17), 3425-3431 (2006)
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