|Other Names||Zyxin, Zyxin-2, ZYX|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6854b was selected from the C-term region of human ZYX. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity).|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Cell junction, focal adhesion. Note=Associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1|
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Provided below are standard protocols that you may find useful for product applications.
ZYX binds alpha-actinin and the CRP protein. It may be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression.
Moon,H.S., et.al., Exp. Cell Res. 312 (17), 3425-3431 (2006)
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