|Other Names||Endothelin-converting enzyme 1, ECE-1, ECE1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6855c was selected from the Center region of human ECE-1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Converts big endothelin-1 to endothelin-1.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein|
|Tissue Location||All isoforms are expressed in umbilical vein endothelial cells, polynuclear neutrophils, fibroblasts, atrium cardiomyocytes and ventricles. Isoforms A, B and C are also expressed in placenta, lung, heart, adrenal gland and phaeochromocytoma; isoforms A and C in liver, testis and small intestine; isoform B, C and D in endothelial cells and umbilical vein smooth muscle cells; isoforms C and D in saphenous vein cells, and isoform C in kidney.|
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Provided below are standard protocols that you may find useful for product applications.
ECE-1 is involved in proteolytic processing of endothelin precursors to biologically active peptides.
Cottrell,G.S., et.al., J. Biol. Chem. 284 (33), 22411-22425 (2009)
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