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CORIN Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9Y5Q5
Clone Names 80325146
Peptide ID 80325146
Additional Information
Gene ID 10699
Other Names Atrial natriuretic peptide-converting enzyme, 3421-, Corin, Heart-specific serine proteinase ATC2, Pro-ANP-converting enzyme, Transmembrane protease serine 10, Atrial natriuretic peptide-converting enzyme, N-terminal propeptide, Atrial natriuretic peptide-converting enzyme, activated protease fragment, Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment, Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment, Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment, CORIN, CRN, TMPRSS10
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6868c was selected from the Center region of human CORIN. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CRN, TMPRSS10
Function Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide.
Cellular Location Cell membrane; Single- pass type II membrane protein Note=May easily detached from the endothelial cell membrane Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment: Secreted. Note=Soluble form produced following cleavage by ADAM10 Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment: Secreted. Note=Soluble form produced following autocatalytic cleavage
Tissue Location Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus. Detected in blood, in plasma as well as in serum (at protein level)
Research Areas
Citations (0)

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CORIN is a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. This protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase.


Fox,A.A.,, Anesthesiology 110 (4), 738-747 (2009)

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$ 80.00
Cat# BP6868c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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