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CCM2 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9BSQ5
Clone Names 90121083
Peptide ID 90121083
Additional Information
Gene ID 83605
Other Names Malcavernin, Cerebral cavernous malformations 2 protein, CCM2, C7orf22
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6875a was selected from the N-term region of human CCM2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCM2
Synonyms C7orf22
Function Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3- dependent p38 activation induced by hyperosmotic shock (By similarity).
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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CCM2 is a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells.


Penco,S.,, J. Neurosurg. 110 (5), 929-934 (2009)

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$ 80.00
Cat# BP6875a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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