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ECHS1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P30084
Clone Names 90415036
Additional Information
Gene ID 1892
Other Names Enoyl-CoA hydratase, mitochondrial, Enoyl-CoA hydratase 1, Short-chain enoyl-CoA hydratase, SCEH, ECHS1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6907b was selected from the C-term region of human ECHS1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ECHS1 (HGNC:3151)
Function Converts unsaturated trans-2-enoyl-CoA species ((2E)-enoyl- CoA) to the corresponding (3S)-3hydroxyacyl-CoA species through addition of a water molecule to the double bond (PubMed:25125611, PubMed:26251176). Catalyzes the hydration of medium- and short-chained fatty enoyl-CoA thioesters from 4 carbons long (C4) up to C16 (PubMed:26251176). Has high substrate specificity for crotonyl-CoA ((2E)-butenoyl-CoA) and moderate specificity for acryloyl-CoA, 3- methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA) and methacrylyl-CoA ((2E)-2-methylpropenoyl-CoA) (PubMed:26251176). Can bind tiglyl-CoA (2- methylcrotonoyl-CoA), but hydrates only a small amount of this substrate (PubMed:26251176). Plays a key role in the beta-oxidation spiral of short- and medium-chain fatty acid oxidation (PubMed:25125611, PubMed:26251176). At a lower rate than the hydratase reaction, catalyzes the isomerase reaction of trans-3-enoyl-CoA species (such as (3E)-hexenoyl-CoA) to trans-2-enoyl-CoA species (such as (2E)- hexenoyl-CoA), which are subsequently hydrated to 3(S)-3-hydroxyacyl- CoA species (such as (3S)-hydroxyhexanoyl-CoA) (By similarity).
Cellular Location Mitochondrion matrix.
Tissue Location Liver, fibroblast, muscle. Barely detectable in spleen and kidney
Research Areas
Citations (0)
citation

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Background

ECHS1 functions in the second step of the mitochondrial fatty acid beta-oxidation pathway. It catalyzes the hydration of 2-trans-enoyl-coenzyme A (CoA) intermediates to L-3-hydroxyacyl-CoAs. It is a member of the hydratase/isomerase superfamily.

References

Bruneel,A., et.al., Proteomics 5 (15), 3876-3884 (2005)

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$ 277.78
Cat# BP6907b
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