|Other Names||NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8, Complex I-19kD, CI-19kD, Complex I-PGIV, CI-PGIV, NADH-ubiquinone oxidoreductase 19 kDa subunit, NDUFA8|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6921c was selected from the Center region of human NDUFA8. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|
|Cellular Location||Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space|
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Provided below are standard protocols that you may find useful for product applications.
NDUFA8 belongs to the complex I 19 kDA subunit family. Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays an important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Loeffen,J.L., et.al., Biochem. Biophys. Res. Commun. 253 (2), 415-422 (1998)
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