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OTC Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P00480 |
|---|---|
| Clone Names | 90625160 |
| Gene ID | 5009 |
|---|---|
| Other Names | Ornithine carbamoyltransferase, mitochondrial, Ornithine transcarbamylase, OTCase, OTC |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6928c was selected from the Center region of human OTC. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | OTC (HGNC:8512) |
|---|---|
| Function | Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline (PubMed:6372096, PubMed:8112735, PubMed:2556444). The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion (PubMed:2556444). |
| Cellular Location | Mitochondrion matrix |
| Tissue Location | Mainly expressed in liver and intestinal mucosa. |
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Provided below are standard protocols that you may find useful for product applications.
Background
OTC is a mitochondrial matrix enzyme. Missense, nonsense, and frameshift mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia.
References
Hansmannel,F., et.al., Neurosci. Lett. 449 (1), 76-80 (2009)
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