|Other Names||Ornithine carbamoyltransferase, mitochondrial, Ornithine transcarbamylase, OTCase, OTC|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6928c was selected from the Center region of human OTC. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Mitochondrion matrix.|
|Tissue Location||Mainly expressed in liver and intestinal mucosa|
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Provided below are standard protocols that you may find useful for product applications.
OTC is a mitochondrial matrix enzyme. Missense, nonsense, and frameshift mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia.
Hansmannel,F., et.al., Neurosci. Lett. 449 (1), 76-80 (2009)
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