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XRCC3 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O43542
Clone Names 90713231
Peptide ID 90713231
Additional Information
Gene ID 7517
Other Names DNA repair protein XRCC3, X-ray repair cross-complementing protein 3, XRCC3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6933c was selected from the Center region of human XRCC3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name XRCC3
Function Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2- dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.
Cellular Location Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Note=Accumulates in discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair
Research Areas
Citations (0)

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XRCC3 is a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage.


Gangwar,R.,, Mutat. Res. (2009)Young,R.P.,, Postgrad Med J 85 (1008), 515-524 (2009)

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$ 80.00
Cat# BP6933c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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