|Other Names||Transmembrane protease serine 3, 3421-, Serine protease TADG-12, Tumor-associated differentially-expressed gene 12 protein, TMPRSS3, ECHOS1, TADG12|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6936c was selected from the Center region of human TMPRSS3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro).|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type II membrane protein|
|Tissue Location||Expressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas|
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Provided below are standard protocols that you may find useful for product applications.
TMPRSS3 belongs to the serine protease family. This protein contains a serine protease domain, a transmembrane domain, a LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders.
Elbracht,M., et.al., J. Med. Genet. 44 (6), E81 (2007)
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