TMPRSS3 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P57727 |
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Clone Names | 90625031 |
Gene ID | 64699 |
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Other Names | Transmembrane protease serine 3, 3421-, Serine protease TADG-12, Tumor-associated differentially-expressed gene 12 protein, TMPRSS3, ECHOS1, TADG12 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP6936c was selected from the Center region of human TMPRSS3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TMPRSS3 |
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Synonyms | ECHOS1, TADG12 |
Function | Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro). |
Cellular Location | Endoplasmic reticulum membrane; Single-pass type II membrane protein |
Tissue Location | Expressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas |
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Provided below are standard protocols that you may find useful for product applications.
Background
TMPRSS3 belongs to the serine protease family. This protein contains a serine protease domain, a transmembrane domain, a LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders.
References
Elbracht,M., et.al., J. Med. Genet. 44 (6), E81 (2007)
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