|Other Names||Insulin-like growth factor-binding protein 4, IBP-4, IGF-binding protein 4, IGFBP-4, IGFBP4, IBP4|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the insulin-like growth factorbinding protein (IGFBP) family and encodes a protein with an IGFBPdomain and a thyroglobulin type-I domain. The protein binds bothinsulin-like growth factors (IGFs) I and II and circulates in theplasma in both glycosylated and non-glycosylated forms. Binding ofthis protein prolongs the half-life of the IGFs and alters theirinteraction with cell surface receptors.
Giroux, S., et al. Bone 47(5):975-981(2010)Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)Bartling, B., et al. Int. J. Mol. Med. 25(1):89-96(2010)Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
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