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IGFBP4 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P22692 |
|---|---|
| Other Accession | NP_001543.2 |
| Clone Names | 81110100 |
| Gene ID | 3487 |
|---|---|
| Other Names | Insulin-like growth factor-binding protein 4, IBP-4, IGF-binding protein 4, IGFBP-4, IGFBP4, IBP4 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | IGFBP4 |
|---|---|
| Synonyms | IBP4 |
| Function | IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. |
| Cellular Location | Secreted. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the insulin-like growth factorbinding protein (IGFBP) family and encodes a protein with an IGFBPdomain and a thyroglobulin type-I domain. The protein binds bothinsulin-like growth factors (IGFs) I and II and circulates in theplasma in both glycosylated and non-glycosylated forms. Binding ofthis protein prolongs the half-life of the IGFs and alters theirinteraction with cell surface receptors.
References
Giroux, S., et al. Bone 47(5):975-981(2010)Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)Bartling, B., et al. Int. J. Mol. Med. 25(1):89-96(2010)Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
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