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DIO1 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P49895
Clone Names 90504045
Additional Information
Gene ID 1733
Other Names Type I iodothyronine deiodinase, 5DI, DIOI, Type 1 DI, Type-I 5'-deiodinase, DIO1, ITDI1, TXDI1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6958a was selected from the N-term region of human DIO1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DIO1
Synonyms ITDI1, TXDI1
Function Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney.
Cellular Location Endoplasmic reticulum membrane; Single-pass membrane protein
Research Areas
Citations (0)
citation

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Background

DIO1 is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD).

References

Landa,I., et.al., PLoS Genet. 5 (9), E1000637 (2009)

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$ 277.78
Cat# BP6958a
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