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CBS Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P35520
Clone Names 90121082
Additional Information
Gene ID 102724560;875
Other Names Cystathionine beta-synthase, Beta-thionase, Serine sulfhydrase, CBS
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6959c was selected from the Center region of human CBS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CBS
Function Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (PubMed:23981774, PubMed:20506325, PubMed:23974653). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity).
Cellular Location Cytoplasm. Nucleus
Tissue Location In the adult strongly expressed in liver and pancreas, some expression in heart and brain, weak expression in lung and kidney. In the fetus, expressed in brain, liver and kidney
Research Areas
Citations (0)
citation

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Background

CBS acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. This protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria.

References

Ravel,C., et.al., PLoS ONE 4 (8), E6540 (2009)

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$ 277.78
Cat# BP6959c
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