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TP53INP2/DOR Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8IXH6
Clone Names 90415006
Additional Information
Gene ID 58476
Other Names Tumor protein p53-inducible nuclear protein 2, Diabetes and obesity-regulated gene, p53-inducible protein U, PIG-U, TP53INP2, C20orf110, DOR, PINH
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6960b was selected from the C-term region of human TP53INP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TP53INP2
Synonyms C20orf110, DOR, PINH
Function Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.
Cellular Location Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re- localizes to autophagosomes on autophagy activation
Research Areas
Citations (0)
citation

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Background

TP53INP2 is a scaffold protein that recruits LC3 and/or LC3-related proteins to the autophagosome membrane by interacting with the transmembrane protein VMP1.

References

Bennetts,J.S., et.al., Dev. Dyn. 236 (3), 843-852 (2007)

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$ 277.78
Cat# BP6960b
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