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PITX3 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O75364
Clone Names 90625176
Additional Information
Gene ID 5309
Other Names Pituitary homeobox 3, Homeobox protein PITX3, Paired-like homeodomain transcription factor 3, PITX3, PTX3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6969a was selected from the N-term region of human PITX3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PITX3
Synonyms PTX3
Function Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138}
Tissue Location Highly expressed in developing eye lens.
Research Areas
Citations (0)
citation

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Background

PITX3 is a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family act as transcription factors. This protein is involved in lens formation during eye development.

References

Martinat,C., et.al., Proc. Natl. Acad. Sci. U.S.A. 103 (8), 2874-2879 (2006)Finzi,S., et.al., Ophthalmic Genet. 26 (3), 125-130 (2005)

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$ 277.78
Cat# BP6969a
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