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FPGS Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q05932
Clone Names 90713065
Peptide ID 90713065
Additional Information
Gene ID 2356
Other Names Folylpolyglutamate synthase, mitochondrial, Folylpoly-gamma-glutamate synthetase, FPGS, Tetrahydrofolylpolyglutamate synthase, Tetrahydrofolate synthase, FPGS
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6975c was selected from the Center region of human FPGS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstitued reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates.
Cellular Location Isoform 1: Mitochondrion inner membrane. Mitochondrion matrix
Research Areas
Citations (0)

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FPGS is the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives.


Sharma,S.,, Pharmacogenet. Genomics 18 (12), 1041-1049 (2008)

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$ 80.00
Cat# BP6975c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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