|Other Names||Methionine-R-sulfoxide reductase B2, mitochondrial, MsrB2, 184-, MSRB2, CBS-1, MSRB|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6980c was selected from the Center region of human MSRB2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post- translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance.|
|Tissue Location||Ubiquitous. Detected in retina, ocular ciliary body, skeletal muscle, heart, colon, bone marrow, cerebellum, small intestine, fetal brain, fetal liver, kidney, spinal cord, lung, placenta and prostate.|
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Provided below are standard protocols that you may find useful for product applications.
MSRB2 catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine.
Cabreiro,F., et.al., J. Biol. Chem. 283 (24), 16673-16681 (2008)
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