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LAG3 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P18627
Clone Names 90713125
Peptide ID 90713125
Additional Information
Other Names Lymphocyte activation gene 3 protein, LAG-3, Protein FDC, CD223, LAG3, FDC
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6987c was selected from the Center region of human LAG3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name LAG3
Synonyms FDC
Function Involved in lymphocyte activation. Binds to HLA class-II antigens.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location On cell surface of activated NK and T- lymphocytes EMBL; X51985; CAA36243.3; -; mRNA EMBL; AK292104; BAF84793.1; -; mRNA EMBL; AC125494; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471116; EAW88741.1; -; Genomic_DNA EMBL; BC052589; AAH52589.1; -; mRNA CCDS; CCDS8561.1; -. [P18627-1] PIR; S11246; S11246 RefSeq; NP_002277.4; NM_002286.5. [P18627-1] UniGene; Hs.409523; - ProteinModelPortal; P18627; - BioGrid; 110097; 14 IntAct; P18627; 3 STRING; 9606.ENSP00000203629; - iPTMnet; P18627; - PhosphoSitePlus; P18627; - BioMuta; LAG3; - DMDM; 251757512; - PaxDb; P18627; - PeptideAtlas; P18627; - PRIDE; P18627; - ProteomicsDB; 53604; - Ensembl; ENST00000203629; ENSP00000203629; ENSG00000089692. [P18627-1] Ensembl; ENST00000441671; ENSP00000413825; ENSG00000089692. [P18627-2] GeneID; 3902; - KEGG; hsa:3902; - UCSC; uc001qqs.4; human. [P18627-1] CTD; 3902; - DisGeNET; 3902; - EuPathDB; HostDB:ENSG00000089692.8; - GeneCards; LAG3; - H-InvDB; HIX0201912; - HGNC; HGNC:6476; LAG3 HPA; CAB002301; - HPA; HPA013967; - MIM; 153337; gene neXtProt; NX_P18627; - OpenTargets; ENSG00000089692; - PharmGKB; PA30265; - eggNOG; ENOG410IFPP; Eukaryota eggNOG; ENOG410Z3KP; LUCA GeneTree; ENSGT00390000017331; - HOGENOM; HOG000113275; - HOVERGEN; HBG004952; - InParanoid; P18627; - KO; K06565; - OMA; GIHPPQA; - OrthoDB; EOG091G0PJF; - PhylomeDB; P18627; - TreeFam; TF335942; - Reactome; R-HSA-2132295; MHC class II antigen presentation GeneWiki; LAG3; - GenomeRNAi; 3902; - PRO; PR:P18627; - Proteomes; UP000005640; Chromosome 12 Bgee; ENSG00000089692; - CleanEx; HS_LAG3; - Genevisible; P18627; HS GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO; GO:0005886; C:plasma membrane; TAS:Reactome GO; GO:0003823; F:antigen binding; TAS:ProtInc GO; GO:0042289; F:MHC class II protein binding; IDA:MGI GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:Ensembl GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; TAS:Reactome GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:Ensembl GO; GO:0045085; P:negative regulation of interleukin-2 biosynthetic process; IEA:Ensembl GO; GO:0050868; P:negative regulation of T cell activation; IEA:Ensembl GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IEA:Ensembl Gene3D; 2.60.40.10; -; 3 InterPro; IPR007110; Ig-like_dom InterPro; IPR036179; Ig-like_dom_sf InterPro; IPR013783; Ig-like_fold InterPro; IPR003599; Ig_sub InterPro; IPR015621; IL-1_rcpt_fam PANTHER; PTHR11890; PTHR11890; 1 SMART; SM00409; IG; 3 SUPFAM; SSF48726; SSF48726; 4 PROSITE; PS50835; IG_LIKE; 2 1: Evidence at protein level; Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix SIGNAL 1 28 CHAIN 29 525 Lymphocyte activation gene 3 protein /FTId=PRO_0000014631 TOPO_DOM 29 450 Extracellular. TRANSMEM 451 471 Helical. TOPO_DOM 472 525 Cytoplasmic. DOMAIN 37 167 Ig-like V-type DOMAIN 168 252 Ig-like C2-type 1 DOMAIN 265 343 Ig-like C2-type 2 DOMAIN 348 419 Ig-like C2-type 3 REGION 501 524 12 X 2 AA tandem repeats of E-X CARBOHYD 188 188 N-linked (GlcNAc...) asparagine CARBOHYD 250 250 N-linked (GlcNAc...) asparagine CARBOHYD 256 256 N-linked (GlcNAc...) asparagine CARBOHYD 343 343 N-linked (GlcNAc...) asparagine DISULFID 44 160 {ECO:0000255|PROSITE-ProRule:PRU00114} DISULFID 189 241 {ECO:0000255|PROSITE-ProRule:PRU00114} DISULFID 282 333 {ECO:0000255|PROSITE-ProRule:PRU00114} DISULFID 369 412 {ECO:0000255|PROSITE-ProRule:PRU00114} VAR_SEQ 353 360 VTPKSFGS -> GQPQVGKE (in isoform 2) /FTId=VSP_056311 VAR_SEQ 361 525 Missing (in isoform 2) /FTId=VSP_056312 VARIANT 455 455 I -> T (in dbSNP:rs870849) {ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:1692078, ECO:0000269|Ref.5} /FTId=VAR_058295 SEQUENCE 525 AA; 57449 MW; 5E0BDEF20E9E36D2 CRC64; MWEAQFLGLL FLQPLWVAPV KPLQPGAEVP VVWAQEGAPA QLPCSPTIPL QDLSLLRRAG VTWQHQPDSG PPAAAPGHPL APGPHPAAPS SWGPRPRRYT VLSVGPGGLR SGRLPLQPRV QLDERGRQRG DFSLWLRPAR RADAGEYRAA VHLRDRALSC RLRLRLGQAS MTASPPGSLR ASDWVILNCS FSRPDRPASV HWFRNRGQGR VPVRESPHHH LAESFLFLPQ VSPMDSGPWG CILTYRDGFN VSIMYNLTVL GLEPPTPLTV YAGAGSRVGL PCRLPAGVGT RSFLTAKWTP PGGGPDLLVT GDNGDFTLRL EDVSQAQAGT YTCHIHLQEQ QLNATVTLAI ITVTPKSFGS PGSLGKLLCE VTPVSGQERF VWSSLDTPSQ RSFSGPWLEA QEAQLLSQPW QCQLYQGERL LGAAVYFTEL SSPGAQRSGR APGALPAGHL LLFLILGVLS LLLLVTGAFG FHLWRRQWRP RRFSALEQGI HPPQAQSKIE ELEQEPEPEP EPEPEPEPEP EPEQL
Research Areas
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Background

Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains.

References

Smyth,D.J., et.al., BMC Med. Genet. 7, 20 (2006)

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$ 80.00
Cat# BP6987c
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