|Other Names||Arylamine N-acetyltransferase 2, Arylamide acetylase 2, N-acetyltransferase type 2, NAT-2, Polymorphic arylamine N-acetyltransferase, PNAT, NAT2, AAC2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP6993b was selected from the C-term region of human NAT2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.|
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Provided below are standard protocols that you may find useful for product applications.
NAT2 is an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens.
Kim,S.H., et.al., Pharmacogenomics 10 (11), 1767-1779 (2009)
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