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ARGBP2 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession O94875
Clone Names 80924062
Peptide ID 80924062
Additional Information
Gene ID 8470
Other Names Sorbin and SH3 domain-containing protein 2, Arg/Abl-interacting protein 2, ArgBP2, Sorbin, SORBS2, ARGBP2, KIAA0777
Target/Specificity The synthetic peptide sequence used to generate the antibody AP6997a was selected from the N-term region of human ARGBP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ARGBP2, KIAA0777
Function Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.
Cellular Location Cytoplasm, perinuclear region Note=Found at the Z-disk sarcomeres, stress fibers, dense bodies and focal adhesion
Tissue Location Abundantly expressed in heart. In cardiac muscle cells, located in the Z-disks of sarcomere. Also found, but to a lower extent, in small and large intestine, pancreas, thymus, colon, spleen, prostate, testis, brain, ovary and epithelial cells.
Research Areas
Citations (0)

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Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. ARGBP2 is the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology(SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton.


Yuan,Z.Q.,, J. Biol. Chem. 280 (22), 21483-21490 (2005)Olsen,J.V.,, Cell 127 (3), 635-648 (2006)Taieb,D.,, Cancer Res. 68 (12), 4588-4596 (2008)

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$ 80.00
Cat# BP6997a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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Ordering Information

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