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GRK1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q15835
Clone Names 2030109
Peptide ID 2030109
Additional Information
Gene ID 6011
Other Names Rhodopsin kinase, RK, G protein-coupled receptor kinase 1, GRK1, RHOK
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7003a was selected from the C-term region of human GRK1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRK1 (HGNC:10013)
Synonyms RHOK
Function Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination.
Cellular Location Membrane {ECO:0000250|UniProtKB:P28327}; Lipid-anchor {ECO:0000250|UniProtKB:P28327}
Tissue Location Retinal-specific. Expressed in rods and cones cells.
Research Areas
Citations (0)

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Background

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK).The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK).

References

Zhao, X., et al., J. Biol. Chem. 273(9):5124-5131 (1998).Zhao, X., et al., Vis. Neurosci. 14(2):225-232 (1997).Yamamoto, S., et al., Nat. Genet. 15(2):175-178 (1997).Khani, S.C., et al., Genomics 35(3):571-576 (1996).Lorenz, W., et al., Proc. Natl. Acad. Sci. U.S.A. 88(19):8715-8719 (1991).

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$ 80.00
Cat# BP7003a
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