|Other Names||G protein-coupled receptor kinase 6, G protein-coupled receptor kinase GRK6, GRK6, GPRK6|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7008a was selected from the C-term region of human GRK6 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).|
|Cellular Location||Membrane; Lipid-anchor.|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
GRK6 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation.
Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).Stoffel, R.H., et al., J. Biol. Chem. 269(45):27791-27794 (1994).Benovic, J.L., et al., J. Biol. Chem. 268(26):19521-19527 (1993).
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