|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7011c was selected from the N-term region of human MSK2 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
MSK2 is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. It has an essential role in the control of RELA transcriptional activity in response to TNF
Zhu, S., et al., Hum. Genet. 103(6):674-680 (1998).Pierrat, B., et al., J. Biol. Chem. 273(45):29661-29671 (1998).Deak, M., et al., EMBO J. 17(15):4426-4441 (1998).
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