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JIK (TAOK3) Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H2K8 |
|---|---|
| Other Accession | Q6DD27, Q53UA7, Q8BYC6, Q9I9E0 |
| Gene ID | 51347 |
|---|---|
| Other Names | Serine/threonine-protein kinase TAO3, Cutaneous T-cell lymphoma-associated antigen HD-CL-09, CTCL-associated antigen HD-CL-09, Dendritic cell-derived protein kinase, JNK/SAPK-inhibitory kinase, Jun kinase-inhibitory kinase, Kinase from chicken homolog A, hKFC-A, Thousand and one amino acid protein 3, TAOK3, DPK, JIK, KDS, MAP3K18 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 686-700 of HUMAN TAOK3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TAOK3 |
|---|---|
| Synonyms | DPK, JIK, KDS, MAP3K18 |
| Function | Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). |
| Cellular Location | Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Also localized to the peripheral cell membrane |
| Tissue Location | Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
TAOK3 is negatively regulated by epidermal growth factor (EGF) and Inhibits the basal activity of Jun kinase. When TAOK3 is overexpressed, it may activate ERK1/ERK2 and JNK/SAPK.
References
Hartmann,T.B.,Br. J. Dermatol. 150 (2), 252-258 (2004)
Yustein,J.T.,Oncogene 22 (40), 6129-6141 (2003)
Yoneda,T.,J. Biol. Chem. 276 (17), 13935-13940 (2001)
Zhang,W.,Biochem. Biophys. Res. Commun. 274 (3), 872-879 (2000)
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