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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   JIK (TAOK3) Blocking Peptide (C-term)   

JIK (TAOK3) Blocking Peptide (C-term)

Synthetic peptide

Product Information
Primary Accession Q9H2K8
Other Accession Q6DD27, Q53UA7, Q8BYC6, Q9I9E0
Additional Information
Gene ID 51347
Other Names Serine/threonine-protein kinase TAO3, Cutaneous T-cell lymphoma-associated antigen HD-CL-09, CTCL-associated antigen HD-CL-09, Dendritic cell-derived protein kinase, JNK/SAPK-inhibitory kinase, Jun kinase-inhibitory kinase, Kinase from chicken homolog A, hKFC-A, Thousand and one amino acid protein 3, TAOK3, DPK, JIK, KDS, MAP3K18
Target/Specificity The synthetic peptide sequence is selected from aa 686-700 of HUMAN TAOK3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TAOK3
Synonyms DPK, JIK, KDS, MAP3K18
Function Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress- activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).
Cellular Location Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Also localized to the peripheral cell membrane
Tissue Location Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver
Research Areas
Citations (0)

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TAOK3 is negatively regulated by epidermal growth factor (EGF) and Inhibits the basal activity of Jun kinase. When TAOK3 is overexpressed, it may activate ERK1/ERK2 and JNK/SAPK.


Hartmann,T.B.,Br. J. Dermatol. 150 (2), 252-258 (2004)
Yustein,J.T.,Oncogene 22 (40), 6129-6141 (2003)
Yoneda,T.,J. Biol. Chem. 276 (17), 13935-13940 (2001)
Zhang,W.,Biochem. Biophys. Res. Commun. 274 (3), 872-879 (2000)

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$ 80.00
$ 99.00
Cat# BP7012b
(40 western blots)
Availability: 2 weeks
Bulk Size
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