|Other Names||cAMP-dependent protein kinase catalytic subunit gamma, PKA C-gamma, PRKACG|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7014a was selected from the N-term region of human PKA/C gamma . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Phosphorylates a large number of substrates in the cytoplasm and the nucleus.|
|Tissue Location||Testis specific. But important tissues such as brain and ovary have not been analyzed for the content of transcript|
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Provided below are standard protocols that you may find useful for product applications.
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (AMPK), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. This protein, the gamma-catalytic subunit, is a member of the Ser/Thr protein kinase family. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the catalytic subunit.
Bodnar, R.J., et al., J. Biol. Chem. 277(49):47080-47087 (2002).Reinton, N., et al., Genomics 49(2):290-297 (1998).Swingler, S., et al., J. Virol. 71(6):4372-4377 (1997).Hofmann, B., et al., AIDS 8(7):1016-1017 (1994).Hofmann, B., et al., Proc. Natl. Acad. Sci. U.S.A. 90(14):6676-6680 (1993).
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