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PKC nu Antibody (C-term) Blocking PeptideSynthetic peptide
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| BP7025b | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
PKC nu Antibody (C-term) Blocking Peptide - Product info | |
| Primary Accession | O94806 |
| Clone Names | 2041703 |
| Calculated MW | 100471 Da |
PKC nu Antibody (C-term) Blocking Peptide - Additional info | |
| Gene ID 23683 | |
| Target/Specificity The synthetic peptide sequence used to generate the antibody AP7025b was selected from the C-term region of human PKC nu . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. | |
| Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
PKC nu Antibody (C-term) Blocking Peptide - Protein Information | |
| Name PRKD3 | |
| Synonyms EPK2, PRKCN | |
| Function Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity) | |
| Cellular Location Cytoplasm. Membrane. Note=Translocation to the cell membrane is required for kinase activation | |
| Tissue Location Ubiquitous. | |
PKC nu Antibody (C-term) Blocking Peptide - Related products
AP7025b: PKC nu Antibody (C-term)
RI14232: PRKD3 predesign siRNA
PKC nu Antibody (C-term) Blocking Peptide - Research Areas
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BACKGROUND
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. PKC nu is one of the PKC family members. This kinase can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phopholipase C gamma and the involvement of other PKC family members.
REFERENCES
Yeaman, C., et al., Nat. Cell Biol. 6(2):106-112 (2004).Rey, O., et al., J. Biol. Chem. 278(26):23773-23785 (2003).Matthews, S.A., et al., J. Biol. Chem. 278(11):9086-9091 (2003).Bennasser, Y., et al., Virology 303(1):174-180 (2002).Bennasser, Y., et al., FASEB J. 16(6):546-554 (2002).
