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PDK1 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q15118
Clone Names 2122302
Peptide ID 2122302
Additional Information
Gene ID 5163
Other Names [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial, Pyruvate dehydrogenase kinase isoform 1, PDH kinase 1, PDK1, PDHK1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7038a was selected from the N-term region of human PDK1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDK1
Synonyms PDHK1
Function Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.
Cellular Location Mitochondrion matrix
Tissue Location Expressed predominantly in the heart. Detected at lower levels in liver, skeletal muscle and pancreas
Research Areas
Citations (0)

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Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation.


Sato, S., et al., J. Biol. Chem. 277(42):39360-39367 (2002).Frodin, M., et al., EMBO J. 21(20):5396-5407 (2002).King, C.C., et al., J. Biol. Chem. 275(24):18108-18113 (2000).Gudi, R., et al., J. Biol. Chem. 270(48):28989-28994 (1995).

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$ 80.00
Cat# BP7038a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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