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PDK3 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q15120
Clone Names 2122304
Peptide ID 2122304
Additional Information
Gene ID 5165
Other Names [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial, Pyruvate dehydrogenase kinase isoform 3, PDK3, PDHK3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7040a was selected from the N-term region of human PDK3 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDK3
Synonyms PDHK3
Function Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species.
Cellular Location Mitochondrion matrix.
Tissue Location Expressed in heart, skeletal muscle, spinal cord, as well as fetal and adult brain
Research Areas
Citations (0)

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PDK3 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.


Baker, J.C., et al., J. Biol. Chem. 275(21):15773-15781 (2000).Gudi, R., et al., J. Biol. Chem. 270(48):28989-28994 (1995).

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$ 80.00
Cat# BP7040a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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