|Other Names||Pyruvate kinase PKLR, Pyruvate kinase 1, Pyruvate kinase isozymes L/R, R-type/L-type pyruvate kinase, Red cell/liver pyruvate kinase, PKLR, PK1, PKL|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7043a was selected from the N-term region of human PKLR . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a key role in glycolysis.|
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Provided below are standard protocols that you may find useful for product applications.
PKLR is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA).
Wang, H., et al., Diabetes 51(9):2861-2865 (2002).Valentini, G., et al., J. Biol. Chem. 277(26):23807-23814 (2002).Mateu, E., et al., Hum. Genet. 110(6):532-544 (2002).Indo, Y., et al., Hum. Mutat. 18(4):308-318 (2001).Acan, N.L., et al., J. Enzym. Inhib. 16(5):457-464 (2001).
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