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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   c-AMPProtein Kinase Catalytic subnunit Antibody (N-term E32) Blocking peptide   

c-AMPProtein Kinase Catalytic subnunit Antibody (N-term E32) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P22694
Clone Names 3050511
Peptide ID 3050511
Additional Information
Gene ID 5567
Other Names cAMP-dependent protein kinase catalytic subunit beta, PKA C-beta, PRKACB
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7047d was selected from the N-term region of human PRKACB . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.
Cellular Location Cytoplasm. Cell membrane. Nucleus. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm.
Tissue Location Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain.
Research Areas
Citations (0)

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cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (AMPK), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. PRKACB is a member of the Ser/Thr protein kinase family and is a catalytic subunit of AMPK.


Dwivedi, Y., et al., Biol. Psychiatry 55(3):234-243 (2004).Cartier, C., et al., J. Biol. Chem. 278(37):35211-35219 (2003).Higuchi, H., et al., EMBO J. 22(8):1790-1800 (2003).Wu, K.J., et al., Oncogene 21(51):7872-7882 (2002).Jiang, C.H., et al., Proc. Natl. Acad. Sci. U.S.A. 98(4):1930-1934 (2001).

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$ 80.00
Cat# BP7047d
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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