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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   AMPK gamma (PRKAG1) Antibody (Center) Blocking peptide   

AMPK gamma (PRKAG1) Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P54619
Other Accession NP_997626
Clone Names 3010801
Peptide ID 3010801
Additional Information
Gene ID 5571
Other Names 5'-AMP-activated protein kinase subunit gamma-1, AMPK gamma1, AMPK subunit gamma-1, AMPKg, PRKAG1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7048c was selected from the Center region of human PRKAG1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.
Research Areas
Citations (0)

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PRKAG1 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK.


Minokoshi, Y., et al., Nature 428(6982):569-574 (2004).Hamilton, S.R., et al., FEBS Lett. 500(3):163-168 (2001).Zidovetzki, R., et al., AIDS Res. Hum. Retroviruses 14(10):825-833 (1998).Reinton, N., et al., Genomics 49(2):290-297 (1998).Stapleton, D., et al., FEBS Lett. 409(3):452-456 (1997).

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$ 80.00
Cat# BP7048c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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