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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   PKA 2 beta (PRKAR2B) Antibody (N-term) Blocking peptide   

PKA 2 beta (PRKAR2B) Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P31323
Other Accession KAP3_HUMAN
Clone Names 3011707
Peptide ID 3011707
Additional Information
Gene ID 5577
Other Names cAMP-dependent protein kinase type II-beta regulatory subunit, PRKAR2B
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7052a was selected from the N-term region of human PRKAR2B . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Cellular Location Cytoplasm. Cell membrane. Note=Colocalizes with PJA2 in the cytoplasm and at the cell membrane
Tissue Location Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible
Research Areas
Citations (0)

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cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.


Levy, F.O., et al., Mol. Endocrinol. 2(12):1364-1373 (1988).

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$ 80.00
Cat# BP7052a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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