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WNK4 (PRKWNK4) Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q96J92
Clone Names 3011710
Additional Information
Gene ID 65266
Other Names Serine/threonine-protein kinase WNK4, Protein kinase lysine-deficient 4, Protein kinase with no lysine 4, WNK4, PRKWNK4
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7055c was selected from the Center region of human PRKWNK4 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name WNK4
Synonyms PRKWNK4
Function Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity).
Cellular Location Cell junction, tight junction. Note=Present exclusively in intercellular junctions in the distal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct. WNK4 is part of the tight junction complex (By similarity).
Tissue Location Expressed in kidney, colon and skin.
Research Areas
Citations (0)

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Background

The WNK4 gene encodes a serine-threonine kinase expressed in distal nephron.[supplied by OMIM]

References

Erlich, P.M., et al., Hypertension 41(6):1191-1195 (2003).Verissimo, F., et al., Oncogene 20(39):5562-5569 (2001).Wilson, F.H., et al., Science 293(5532):1107-1112 (2001).

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$ 80.00
Cat# BP7055c
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