|Other Names||Thymidylate kinase, dTMP kinase, DTYMK, CDC8, TMPK, TYMK|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7060a was selected from the N-term region of human DTYMK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CDC8, TMPK, TYMK|
|Function||Catalyzes the conversion of dTMP to dTDP.|
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Provided below are standard protocols that you may find useful for product applications.
Thymidylate kinase (DTYMK) catalyzes the phosphorylation of dTMP to form dTDP in the dTTP synthesis pathway for DNA synthesis. DTYMK is essential for DNA synthesis and is an important intermediate enzyme in the pathway of many pyrimidine analog drugs, including 5-Fluorouracil (5-FU), the chemotherapeutic drug of choice for several solid tumors. The human DTYMK gene was isolated via functional complementation of a Saccharomyces cerevisiae cell cycle mutant, cdc8. DTYMK mRNA levels and enzyme activities are regulated at the level of cell cycle and cell growth pathways.
Huang, S.H., et al., DNA Cell Biol. 13(5):461-471 (1994).Su, J.Y., et al., Nucleic Acids Res. 19(4):823-827 (1991).Tamiya, N., et al., Biochim. Biophys. Acta 995(1):28-35 (1989).Cummins, R.R., et al., Cancer Res. 40(4):1235-1239 (1980).Van Rompay, A.R., et al., Pharmacol. Ther. 87 (2-3), 189-198 (2000).
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