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Thymidine Kinase 2 Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O00142
Clone Names 4012111
Peptide ID 4012111
Additional Information
Gene ID 7084
Other Names Thymidine kinase 2, mitochondrial, Mt-TK, TK2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7062b was selected from the C-term region of human TK2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TK2
Function Deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine. Also phosphorylates anti-viral and anti-cancer nucleoside analogs.
Cellular Location Mitochondrion.
Tissue Location Predominantly expressed in liver, pancreas, muscle, and brain
Research Areas
Citations (0)

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Thymidine kinase-2 (TK2) is a deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine, and also phosphorylates antiviral and anticancer nucleoside analogs. Both recombinant and native forms of the enzyme have broad substrate specificity and complex kinetics, suggesting that it may play a role in the activation of chemotherapeutic nucleoside analogs. The highest levels of expression are observed in testis and ovary. The main supply of deoxyribonucleotides (dNTPs) for mitochondrial DNA synthesis comes from the salvage pathway initiated by deoxyguanosine kinase (DGK) and TK2. The association of mitochondrial DNA depletion with mutations in the genes encoding these 2 kinases suggests that the salvage pathway enzymes are involved in the maintenance of balanced mitochondrial dNTP pools.

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$ 80.00
Cat# BP7062b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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