|Other Names||Choline/ethanolamine kinase, Choline kinase beta, CK, CKB, Choline kinase-like protein, Ethanolamine kinase, EK, Ethanolamine kinase beta, EKB, choline/ethanolamine kinase beta, CKEKB, CHKB, CHETK, CHKL|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7066a was selected from the N-term region of human CHKL. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis.|
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Provided below are standard protocols that you may find useful for product applications.
The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family. Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein.
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