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STK38 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q15208
Clone Names 6030501
Peptide ID 6030501
Additional Information
Gene ID 11329
Other Names Serine/threonine-protein kinase 38, NDR1 protein kinase, Nuclear Dbf2-related kinase 1, STK38 {ECO:0000312|EMBL:AAH120851}
Target/Specificity The synthetic peptide sequence used to generate the antibody AP7074c was selected from the Center region of human STK38. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name STK38 {ECO:0000312|EMBL:AAH12085.1}
Function Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2.
Cellular Location Nucleus. Cytoplasm.
Tissue Location Ubiquitously expressed with highest levels observed in peripheral blood leukocytes
Research Areas
Citations (0)

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stk38,also known as NUCLEAR DBF2-RELATED PROTEIN, contains 1 protein kinase domain that interacts with mob1 and mob2.The homodimeric s100b binds to two molecules of stk38. It is ubiquitously expressed with highest levels observed in peripheral blood leukocytes. Stk38 activated by binding of s100b which releases autoinhibitory n-lobe interactions, enabling atp to bind and the autophosphorylation of ser-281. thr-444 then undergoes calcium- dependent phosphorylation by an upstream kinase. Interactions between phosphorylated thr-444 and the n-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of mob1/mobkl1a and mob2/hcca2 to the n-terminal of stk38.


Devroe, E., et al., J. Biol. Chem. 279(23):24444-24451 (2004).Tamaskovic, R., et al., J. Biol. Chem. 278(9):6710-6718 (2003).Tripodis, N., et al., Genome Res. 8(6):631-643 (1998).Millward, T., et al., Proc. Natl. Acad. Sci. U.S.A. 92(11):5022-5026 (1995).

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$ 80.00
Cat# BP7074c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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