|Other Names||Casein kinase II subunit beta, CK II beta, Phosvitin, Protein G5a, CSNK2B, CK2N, G5A|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP7075b was selected from the C-term region of human CSNK2B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.|
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Provided below are standard protocols that you may find useful for product applications.
Phosvitin/casein kinase type II (CKII) is a ubiquitous, highly conserved enzyme consisting of subunits alpha, alpha-prime, and beta. It is a ubiquitous messenger-independent serine/threonine kinase, localized in both the cytoplasm and the nucleus. The beta subunit presumably serves regulatory functions. CKII has been shown to be involved in a potential mechanism for p53 activation by UV irradiation.
Schwartz, E.I., et al., Mol. Cell. Biol. 24(21):9580-9591 (2004). Lee, G., et al., J. Biol. Chem. 279(8):6834-6839 (2004). Lim, A.C., et al., J. Biol. Chem. 279(6):4433-4439 (2004). Singh, D.K., et al., Virology 313(2):435-451 (2003). Kim, Y.S., et al., J. Biol. Chem. 278(31):28462-28469 (2003).
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